A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

Abstract Antipsychotic drugs are commonly prescribed for different mental disorders and can be classified into two main groups: the first which contain originally developed antipsychotics of generation or typical other group with newly atypical second generation. In this study, eleven antipsychotic (chlorpromazine, flupentixol, haloperidol, zuclopenthixol, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone) were investigated to evaluate significance their molecular physicochemical properties (lipophilicity, aqueous solubility, polar surface area, weight, volume value acidity) bioavailability. Relationships between literature available intestinal absorption data lipophilicity descriptor one additional descriptor, using multiple linear regression analysis provided high correlations descriptors, Mw, Vol, pKa, as independent variables. Values correlation coefficients (R 2 ) ranged from 0.951 (for Vol) above 0.944 Mw) 0.923 pKa).